Human TIF1 alpha (TRIM24) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TRIM24
Locus ID	8805
Kit Components	GA105851G1, TIF1 alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105851G2, TIF1 alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105851G3, TIF1 alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_003852, NM_015905
Synonyms	hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1A; TIF1ALPHA
Summary	The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

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