Human SIGLEC5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SIGLEC5
Locus ID	8778
Kit Components	GA105829G1, SIGLEC5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105829G2, SIGLEC5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105829G3, SIGLEC5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_003830
Synonyms	CD33L2; CD170; OB-BP2; OBBP2; SIGLEC-5
Summary	This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]

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