Human DDX3Y activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DDX3Y
Locus ID	8653
Kit Components	GA105735G1, DDX3Y gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105735G2, DDX3Y gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105735G3, DDX3Y gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001122665, NM_001302552, NM_004660, NM_001324195, NR_136716, NR_136717, NR_136718, NR_136719, NR_136720, NR_136721, NR_136722, NR_136723, NR_136724
Synonyms	DBY
Summary	The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

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