Human Apoptosis inhibitor 5 (API5) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	API5
Locus ID	8539
Kit Components	GA105653G1, Apoptosis inhibitor 5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105653G2, Apoptosis inhibitor 5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105653G3, Apoptosis inhibitor 5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001142930, NM_001142931, NM_001243747, NM_006595, NM_021112, NR_024625
Synonyms	AAC-11; AAC11
Summary	This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

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