Human LTBP4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LTBP4
Locus ID	8425
Kit Components	GA105563G1, LTBP4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105563G2, LTBP4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105563G3, LTBP4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001042544, NM_001042545, NM_003573
Synonyms	ARCL1C; LTBP-4; LTBP4L; LTBP4S
Summary	The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

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