Human Frizzled 6 (FZD6) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	FZD6
Locus ID	8323
Kit Components	GA105488G1, Frizzled 6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105488G2, Frizzled 6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105488G3, Frizzled 6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001164615, NM_001164616, NM_001317796, NM_003506, NR_133921
Synonyms	FZ-6; FZ6; HFZ6; NDNC10
Summary	This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

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