Human ApoER2 (LRP8) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LRP8
Locus ID	7804
Kit Components	GA105321G1, ApoER2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105321G2, ApoER2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105321G3, ApoER2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001018054, NM_004631, NM_017522, NM_033300
Synonyms	APOER2; HSZ75190; LRP-8; MCI1
Summary	This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

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