Human RIZ1 (PRDM2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PRDM2
Locus ID	7799
Kit Components	GA105318G1, RIZ1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105318G2, RIZ1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105318G3, RIZ1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001007257, NM_001135610, NM_012231, NM_015866
Synonyms	HUMHOXY1; KMT8; MTB-ZF; RIZ; RIZ1; RIZ2
Summary	This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

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