Human Tryptophan rich protein (WRB) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GET1
Locus ID	7485
Kit Components	GA105161G1, Tryptophan rich protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105161G2, Tryptophan rich protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105161G3, Tryptophan rich protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001146218, NM_004627, NM_001350293, NM_001350294, NM_001350295, NM_001350296, NR_146614, NR_146615, NR_146616
Synonyms	CHD5
Summary	This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. [provided by RefSeq, Apr 2017]

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