Human Rad6 (UBE2A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	UBE2A
Locus ID	7319
Kit Components	GA105039G1, Rad6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105039G2, Rad6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105039G3, Rad6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001282161, NM_003336, NM_181762, NM_181777
Synonyms	HHR6A; MRXS30; MRXSN; RAD6A; UBC2
Summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

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