Human Mps1 (TTK) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TTK
Locus ID	7272
Kit Components	GA105006G1, Mps1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105006G2, Mps1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105006G3, Mps1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001166691, NM_003318
Synonyms	CT96; ESK; MPH1; MPS1; MPS1L1; PYT
Summary	This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

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