Human Translin (TSN) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TSN
Locus ID	7247
Kit Components	GA104985G1, Translin gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104985G2, Translin gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104985G3, Translin gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001261401, NM_004622, NR_048556, NR_048557, NR_048558, NR_048559
Synonyms	BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN
Summary	This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

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