Human TLE4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TLE4
Locus ID	7091
Kit Components	GA104892G1, TLE4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104892G2, TLE4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104892G3, TLE4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001282748, NM_001282749, NM_001282753, NM_001282760, NM_007005, NR_104239, NM_001351541, NM_001351542, NM_001351543, NM_001351546, NM_001351547, NM_001351550, NM_001351552, NM_001351556, NM_001351558, NM_001351560, NM_001351562, NM_001351563, NM_001351564
Synonyms	BCE-1; BCE1; E(spI); ESG; ESG4; Grg-4; GRG4
Summary	Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).[UniProtKB/Swiss-Prot Function]

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