Human Thymidine Kinase 1 (TK1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TK1
Locus ID	7083
Kit Components	GA104885G1, Thymidine Kinase 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104885G2, Thymidine Kinase 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104885G3, Thymidine Kinase 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_003258, NM_001346663, NM_001363848
Synonyms	TK2
Summary	The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]

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