Human Bax inhibitor 1 (TMBIM6) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TMBIM6
Locus ID	7009
Kit Components	GA104820G1, Bax inhibitor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104820G2, Bax inhibitor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104820G3, Bax inhibitor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001098576, NM_003217
Synonyms	BAXI1; BI-1; TEGT
Summary	Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).[UniProtKB/Swiss-Prot Function]

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