Human Thymine DNA glycosylase (TDG) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TDG
Locus ID	6996
Kit Components	GA104810G1, Thymine DNA glycosylase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104810G2, Thymine DNA glycosylase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104810G3, Thymine DNA glycosylase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001008411, NM_003211, NM_001363612
Synonyms	E130317C12Rik; JZA-3; Jza1; OTTMUSP00000028912; OTTMUSP00000028913; thymine DNA glycosylase
Summary	The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]

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