Human TCF7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TCF7
Locus ID	6932
Kit Components	GA104783G1, TCF7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104783G2, TCF7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104783G3, TCF7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001134851, NM_001134852, NM_003202, NM_201632, NM_201633, NM_201634, NM_213648, NR_033449, NM_001346425, NM_001346450, NM_001366502
Synonyms	TCF-1
Summary	This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]

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