Human SUPV3L1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SUPV3L1
Locus ID	6832
Kit Components	GA104700G1, SUPV3L1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104700G2, SUPV3L1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104700G3, SUPV3L1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001301683, NM_001323584, NM_001323585, NM_001323586, NM_001323587, NM_001323588, NM_003171, NR_136626, NR_136627
Synonyms	SUV3
Summary	Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.[UniProtKB/Swiss-Prot Function]

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