Human RO60 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RO60
Locus ID	6738
Kit Components	GA104634G1, RO60 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104634G2, RO60 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104634G3, RO60 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001042369, NM_001042370, NM_001173524, NM_001173525, NM_004600, NR_033393, NM_001331020
Synonyms	RO60; RORNP; SSA2
Summary	RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation (PubMed:18056422). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853).[UniProtKB/Swiss-Prot Function]

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