Human Osteopontin (SPP1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SPP1
Locus ID	6696
Kit Components	GA104596G1, Osteopontin gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104596G2, Osteopontin gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104596G3, Osteopontin gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000582, NM_001040058, NM_001040060, NM_001251829, NM_001251830
Synonyms	BNSP; BSPI; ETA-1; OPN
Summary	The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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