Human SP100 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SP100
Locus ID	6672
Kit Components	GA104580G1, SP100 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104580G2, SP100 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104580G3, SP100 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001080391, NM_001206701, NM_001206702, NM_001206703, NM_001206704, NM_003113
Synonyms	lysp100b
Summary	This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]

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