Human Sorbitol Dehydrogenase (SORD) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SORD
Locus ID	6652
Kit Components	GA104562G1, Sorbitol Dehydrogenase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104562G2, Sorbitol Dehydrogenase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104562G3, Sorbitol Dehydrogenase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_003104, NR_034039
Synonyms	HEL-S-95n; SORD1
Summary	Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]

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