Human Slap (SLA) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SLA
Locus ID	6503
Kit Components	GA104428G1, Slap gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104428G2, Slap gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104428G3, Slap gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001045556, NM_001045557, NM_001282964, NM_001282965, NM_006748
Synonyms	SLA1; SLAP
Summary	Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.[UniProtKB/Swiss-Prot Function]

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