Human RRAD activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RRAD
Locus ID	6236
Kit Components	GA104226G1, RRAD gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104226G2, RRAD gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104226G3, RRAD gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001128850, NM_004165, N93445
Synonyms	RAD; RAD1; REM3
Summary	May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.[UniProtKB/Swiss-Prot Function]

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