Human ROR gamma (RORC) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RORC
Locus ID	6097
Kit Components	GA104132G1, ROR gamma gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104132G2, ROR gamma gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104132G3, ROR gamma gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001001523, NM_005060
Synonyms	IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR
Summary	The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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