Human Poliovirus Receptor (PVR) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PVR
Locus ID	5817
Kit Components	GA103955G1, Poliovirus Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103955G2, Poliovirus Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103955G3, Poliovirus Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001135768, NM_001135769, NM_001135770, NM_006505
Synonyms	CD155; HVED; Necl-5; NECL5; PVS; TAGE4
Summary	The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

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