Human Prostaglandin D Synthase (PTGDS) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PTGDS
Locus ID	5730
Kit Components	GA103896G1, Prostaglandin D Synthase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103896G2, Prostaglandin D Synthase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103896G3, Prostaglandin D Synthase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000954
Synonyms	L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2
Summary	The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

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