Human Protein C (PROC) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PROC
Locus ID	5624
Kit Components	GA103810G1, Protein C gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103810G2, Protein C gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103810G3, Protein C gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000312
Synonyms	APC; PC; PROC1; THPH3; THPH4
Summary	This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

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