Human PKR (EIF2AK2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	EIF2AK2
Locus ID	5610
Kit Components	GA103800G1, PKR gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103800G2, PKR gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103800G3, PKR gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001135651, NM_001135652, NM_002759
Synonyms	EIF2AK1; PKR; PPP1R83; PRKR
Summary	The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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