Human JNK1 (MAPK8) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MAPK8
Locus ID	5599
Kit Components	GA103789G1, JNK1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103789G2, JNK1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103789G3, JNK1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001278547, NM_001278548, NM_001323302, NM_001323320, NM_001323321, NM_001323322, NM_001323323, NM_001323324, NM_001323325, NM_001323326, NM_001323327, NM_001323328, NM_001323329, NM_001323330, NM_001323331, NM_002750, NM_139046, NM_139047, NM_139049, NR_136583, NR_136584, NR_136585
Synonyms	JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
Summary	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

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