Human NIPP1 (PPP1R8) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PPP1R8
Locus ID	5511
Kit Components	GA103713G1, NIPP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103713G2, NIPP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103713G3, NIPP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_002713, NM_014110, NM_138558
Synonyms	ARD-1; ARD1; NIPP-1; NIPP1; PRO2047
Summary	This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

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