Human PPOX activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PPOX
Locus ID	5498
Kit Components	GA103703G1, PPOX gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103703G2, PPOX gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103703G3, PPOX gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000309, NM_001122764, NM_001350128, NM_001350129, NM_001350130, NM_001350131, NM_001365398, NM_001365399, NM_001365400, NM_001365401
Synonyms	PPO; V290M; VP
Summary	This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

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