Human RPB2 (POLR2B) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	POLR2B
Locus ID	5431
Kit Components	GA103654G1, RPB2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103654G2, RPB2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103654G3, RPB2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000938, NM_001303268, NM_001303269
Synonyms	hRPB140; POL2RB; RPB2
Summary	This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

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