Human PMM2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PMM2
Locus ID	5373
Kit Components	GA103628G1, PMM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103628G2, PMM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103628G3, PMM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000303
Synonyms	CDG1; CDG1a; CDGS; PMI; PMI1; PMM 2
Summary	The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq, Jul 2008]

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