Human PI 3 Kinase Class 3 (PIK3C3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PIK3C3
Locus ID	5289
Kit Components	GA103554G1, PI 3 Kinase Class 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103554G2, PI 3 Kinase Class 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103554G3, PI 3 Kinase Class 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001308020, NM_002647
Synonyms	hVps34; VPS34; Vps34
Summary	Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).[UniProtKB/Swiss-Prot Function]

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