Human PIGA activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PIGA
Locus ID	5277
Kit Components	GA103546G1, PIGA gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103546G2, PIGA gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103546G3, PIGA gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_002641, NM_020472, NM_020473, NR_033835, NR_033836
Synonyms	GPI3; MCAHS2; PIG-A; PNH1
Summary	This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]

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