Human PDGF Receptor beta (PDGFRB) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PDGFRB
Locus ID	5159
Kit Components	GA103456G1, PDGF Receptor beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103456G2, PDGF Receptor beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103456G3, PDGF Receptor beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_002609, NM_001355016, NM_001355017, NR_149150
Synonyms	CD140B; IBGC4; IMF1; JTK12; PDGFR; PDGFR-1; PDGFR1
Summary	The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]

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