Human PDGF Receptor alpha (PDGFRA) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PDGFRA
Locus ID	5156
Kit Components	GA103453G1, PDGF Receptor alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103453G2, PDGF Receptor alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103453G3, PDGF Receptor alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_006206, NM_001347827, NM_001347828, NM_001347829, NM_001347830
Synonyms	CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Summary	This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]

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