Human PDE1B activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PDE1B
Locus ID	5153
Kit Components	GA103450G1, PDE1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103450G2, PDE1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103450G3, PDE1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000924, NM_001165975, NM_001288768, NM_001288769, NM_001315534, NM_001315535
Synonyms	PDE1B1; PDES1B
Summary	The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

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