Human PCBD1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PCBD1
Locus ID	5092
Kit Components	GA103403G1, PCBD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103403G2, PCBD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103403G3, PCBD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000281, NM_001001939, NM_001289797, NM_001323004
Synonyms	DCOH; PCBD; PCD; PHS
Summary	This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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