Human OGG1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	OGG1
Locus ID	4968
Kit Components	GA103313G1, OGG1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103313G2, OGG1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103313G3, OGG1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_002542, NM_016819, NM_016820, NM_016821, NM_016826, NM_016827, NM_016828, NM_016829, NM_001354648, NM_001354649, NM_001354650, NM_001354651, NM_001354652, NR_148930, NR_148931, NR_148932
Synonyms	HMMH; HOGG1; MUTM; OGH1
Summary	This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

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