Human TrkA (NTRK1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NTRK1
Locus ID	4914
Kit Components	GA103281G1, TrkA gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103281G2, TrkA gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103281G3, TrkA gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001007204, NM_001007792, NM_001012331, NM_002529
Synonyms	MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA
Summary	This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

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