Human Myosin VIIa (MYO7A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MYO7A
Locus ID	4647
Kit Components	GA103086G1, Myosin VIIa gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103086G2, Myosin VIIa gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103086G3, Myosin VIIa gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000260, NM_001127179, NM_001127180, NM_001369365
Synonyms	DFNA11; DFNB2; MYOVIIA; MYU7A; NSRD2; USH1B
Summary	This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

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