Human MYD88 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MYD88
Locus ID	4615
Kit Components	GA103058G1, MYD88 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103058G2, MYD88 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103058G3, MYD88 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001172566, NM_001172567, NM_001172568, NM_001172569, NM_002468, NM_001365877, NM_001365876
Synonyms	MYD88D
Summary	This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

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