Human IF 2(Mt) (MTIF2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MTIF2
Locus ID	4528
Kit Components	GA103016G1, IF 2(Mt) gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103016G2, IF 2(Mt) gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103016G3, IF 2(Mt) gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001005369, NM_001321001, NM_001321002, NM_001321003, NM_001321004, NM_001321005, NM_002453
Synonyms	IF-2mt; mitochondrial translational initiation factor 2
Summary	During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]

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