Human MSH4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MSH4
Locus ID	4438
Kit Components	GA102979G1, MSH4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102979G2, MSH4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102979G3, MSH4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_002440
Synonyms	mutS homolog 4; mutS homolog 4 (E. coli); OTTHUMP00000011349
Summary	This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]

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