Human MLK3 (MAP3K11) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MAP3K11
Locus ID	4296
Kit Components	GA102922G1, MLK3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102922G2, MLK3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102922G3, MLK3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_002419
Synonyms	MEKK11; MLK-3; MLK3; PTK1; SPRK
Summary	The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

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