Human MEKK1 (MAP3K1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MAP3K1
Locus ID	4214
Kit Components	GA102871G1, MEKK1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102871G2, MEKK1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102871G3, MEKK1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_005921
Synonyms	MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6
Summary	The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

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