Human DNA Ligase I (LIG1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LIG1
Locus ID	3978
Kit Components	GA102694G1, DNA Ligase I gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102694G2, DNA Ligase I gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102694G3, DNA Ligase I gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000234, NM_001289063, NM_001289064, NM_001320970, NM_001320971, NR_110296, NR_135497, NR_135498, NR_135499, NR_135500, NR_135501
Synonyms	MGC117397; MGC130025
Summary	This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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