Human Integrin alpha 6 (ITGA6) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ITGA6
Locus ID	3655
Kit Components	GA102449G1, Integrin alpha 6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102449G2, Integrin alpha 6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102449G3, Integrin alpha 6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000210, NM_001079818, NM_001316306, NM_001365529, NM_001365530
Synonyms	CD49f; ITGA6B; VLA-6
Summary	The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

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